diff --git a/onnxruntime/python/tools/quantization/onnx_quantizer.py b/onnxruntime/python/tools/quantization/onnx_quantizer.py
index ab58143e9c..c1c2248bc8 100644
--- a/onnxruntime/python/tools/quantization/onnx_quantizer.py
+++ b/onnxruntime/python/tools/quantization/onnx_quantizer.py
@@ -111,6 +111,7 @@ class ONNXQuantizer:
         self.is_activation_symmetric = (
             False if "ActivationSymmetric" not in self.extra_options else self.extra_options["ActivationSymmetric"]
         )
+        self.min_real_range = self.extra_options.get("MinimumRealRange")
 
         self.activation_qType = getattr(activation_qType, "tensor_type", activation_qType)
         self.weight_qType = getattr(weight_qType, "tensor_type", weight_qType)
@@ -998,6 +999,7 @@ class ONNXQuantizer:
             qType,
             self.is_weight_symmetric,
             self.reduce_range and reduce_range,
+            self.min_real_range,
         )
 
         if qType in {
@@ -1087,6 +1089,7 @@ class ONNXQuantizer:
                 self.is_weight_symmetric
                 or weight_qType in (onnx_proto.TensorProto.INT8, onnx_proto.TensorProto.FLOAT8E4M3FN),
                 self.reduce_range and reduce_range,
+                self.min_real_range,
             )
             rmin_list.append(rmin)
             rmax_list.append(rmax)
@@ -1208,7 +1211,9 @@ class ONNXQuantizer:
                 rmin, rmax = td.range_value
                 qmin, qmax = get_qmin_qmax_for_qType(self.activation_qType, symmetric=self.is_activation_symmetric)
 
-                zero, scale = compute_scale_zp(rmin, rmax, qmin, qmax, self.is_activation_symmetric)
+                zero, scale = compute_scale_zp(
+                    rmin, rmax, qmin, qmax, self.is_activation_symmetric, self.min_real_range
+                )
             quantization_params[tensor_name] = QuantizationParams(zero_point=zero, scale=scale)
 
         return quantization_params
diff --git a/onnxruntime/python/tools/quantization/quant_utils.py b/onnxruntime/python/tools/quantization/quant_utils.py
index 739e399042..8825d78993 100644
--- a/onnxruntime/python/tools/quantization/quant_utils.py
+++ b/onnxruntime/python/tools/quantization/quant_utils.py
@@ -184,7 +184,7 @@ def quantize_nparray(qType, arr, scale, zero_point, low=None, high=None):
         return arr_fp32.astype(dtype)
 
 
-def compute_scale_zp(rmin, rmax, qmin, qmax, symmetric=False):
+def compute_scale_zp(rmin, rmax, qmin, qmax, symmetric=False, min_real_range=None):
     """Calculate the scale s and zero point z for the quantization relation
     r = s(q-z), where r are the original values and q are the corresponding
     quantized values.
@@ -199,6 +199,8 @@ def compute_scale_zp(rmin, rmax, qmin, qmax, symmetric=False):
     :parameter rmax: maximum value of r
     :parameter qmin: minimum value representable by the target quantization data type
     :parameter qmax: maximum value representable by the target quantization data type
+    :parameter symmetric: True if the floating-point range should be made symmetric. Defaults to False.
+    :parameter min_real_range: Minimum floating-point range (i.e., rmax - rmin) to enforce. Defaults to None.
     :return: zero and scale [z, s]
 
     """
@@ -211,6 +213,10 @@ def compute_scale_zp(rmin, rmax, qmin, qmax, symmetric=False):
     rmin = min(rmin, 0)
     rmax = max(rmax, 0)
 
+    # Ensure a minimum float-point range if specified.
+    if min_real_range is not None:
+        rmax = max(rmax, rmin + min_real_range)
+
     if symmetric:
         absmax = max(abs(rmin), abs(rmax))
         rmin = -absmax
@@ -254,11 +260,13 @@ def compute_scale_zp_float8(element_type, std):
     return [zero, scale]
 
 
-def quantize_data(data, qType, symmetric, reduce_range=False):
+def quantize_data(data, qType, symmetric, reduce_range=False, min_real_range=None):
     """
     :param data: data to quantize
     :param qType: data type to quantize to. Supported types UINT8 and INT8
     :param symmetric: whether symmetric quantization is used or not. This is applied to INT8.
+    :parameter reduce_range: True if the quantization range should be reduced. Defaults to False.
+    :parameter min_real_range: Minimum floating-point range (i.e., rmax - rmin) to enforce. Defaults to None.
     :return: minimum, maximum, zero point, scale, and quantized weights
 
     To pack weights, we compute a linear transformation
@@ -301,7 +309,7 @@ def quantize_data(data, qType, symmetric, reduce_range=False):
     if qType in (TensorProto.INT8, TensorProto.UINT8, TensorProto.INT16, TensorProto.UINT16):
         if len(data):
             qmin, qmax = get_qmin_qmax_for_qType(qType, reduce_range, symmetric=symmetric)
-            zero_point, scale = compute_scale_zp(rmin, rmax, qmin, qmax, symmetric)
+            zero_point, scale = compute_scale_zp(rmin, rmax, qmin, qmax, symmetric, min_real_range)
         quantized_data = quantize_nparray(qType, numpy.asarray(data), scale, zero_point)
         return rmin, rmax, zero_point, scale, quantized_data
 
diff --git a/onnxruntime/python/tools/quantization/quantize.py b/onnxruntime/python/tools/quantization/quantize.py
index 0fdd64fdd3..c9e9a92e2a 100644
--- a/onnxruntime/python/tools/quantization/quantize.py
+++ b/onnxruntime/python/tools/quantization/quantize.py
@@ -370,6 +370,12 @@ def quantize_static(
                     `com.microsoft` domain, which forces use of ONNX Runtime's QuantizeLinear and DequantizeLinear
                     contrib op implementations. The contrib op implementations may support features not standardized
                     into the ONNX specification (e.g., 16-bit quantization types).
+                MinimumRealRange = float|None :
+                    Default is None. If set to a floating-point value, the calculation of the quantization parameters
+                    (i.e., scale and zero point) will enforce a minimum range between rmin and rmax. If (rmax - rmin)
+                    is less than the specified minimum range, rmax will be set to rmin + MinimumRealRange. This is
+                    necessary for EPs like QNN that require a minimum floating-point range when determining
+                    quantization parameters.
     """
     if activation_type == QuantType.QFLOAT8E4M3FN or weight_type == QuantType.QFLOAT8E4M3FN:
         if calibrate_method != CalibrationMethod.Distribution:
diff --git a/onnxruntime/test/python/quantization/test_minimum_real_range_option.py b/onnxruntime/test/python/quantization/test_minimum_real_range_option.py
new file mode 100644
index 0000000000..77f95ab903
--- /dev/null
+++ b/onnxruntime/test/python/quantization/test_minimum_real_range_option.py
@@ -0,0 +1,106 @@
+#!/usr/bin/env python
+# -------------------------------------------------------------------------
+# Copyright (c) Microsoft Corporation. All rights reserved.
+# Licensed under the MIT License. See License.txt in the project root for
+# license information.
+# --------------------------------------------------------------------------
+
+import unittest
+
+import numpy as np
+import onnx
+from onnx import TensorProto, helper, numpy_helper
+
+from onnxruntime import quantization
+
+
+class TestMinimumRealRangeOption(unittest.TestCase):
+    def setUp(self):
+        self.qdq_model_name = "model_qdq_u8.onnx"
+
+        # Set up activations/weights with zero value ranges (i.e., rmax - rmax == 0).
+        self.zero_range_activations = [
+            np.zeros([1, 2, 32, 32], dtype="float32"),
+        ]
+
+        self.zero_range_weights = np.zeros([1, 2, 2, 2], dtype="float32")
+
+    def perform_quantization(self, activations, weight, min_real_range):
+        # One-layer convolution model to be quantized with uint8 activations and uint8 weights.
+        act = helper.make_tensor_value_info("ACT", TensorProto.FLOAT, activations[0].shape)
+        helper.make_tensor_value_info("WGT", TensorProto.FLOAT, weight.shape)
+        res = helper.make_tensor_value_info("RES", TensorProto.FLOAT, [None, None, None, None])
+        wgt_init = numpy_helper.from_array(weight, "WGT")
+        conv_node = onnx.helper.make_node("Conv", ["ACT", "WGT"], ["RES"])
+        graph = helper.make_graph([conv_node], "test", [act], [res], initializer=[wgt_init])
+        model = helper.make_model(graph, opset_imports=[helper.make_opsetid("", 11)])
+        onnx.save(model, "model.onnx")
+
+        # Quantize model
+        class DummyDataReader(quantization.CalibrationDataReader):
+            def __init__(self):
+                self.iterator = ({"ACT": act} for act in activations)
+
+            def get_next(self):
+                return next(self.iterator, None)
+
+        quantization.quantize_static(
+            model_input="model.onnx",
+            model_output=self.qdq_model_name,
+            calibration_data_reader=DummyDataReader(),
+            quant_format=quantization.QuantFormat.QDQ,
+            activation_type=quantization.QuantType.QUInt8,
+            weight_type=quantization.QuantType.QUInt8,
+            op_types_to_quantize=["Conv"],
+            extra_options={"MinimumRealRange": min_real_range},
+        )
+
+        # Extract quantization parameters: scales and zero points for activations and weights.
+        model = onnx.load(self.qdq_model_name)
+        act_zp = next(init for init in model.graph.initializer if init.name == "ACT_zero_point").int32_data[0]
+        act_sc = next(init for init in model.graph.initializer if init.name == "ACT_scale").float_data[0]
+        wgt_zp = next(init for init in model.graph.initializer if init.name == "WGT_zero_point").int32_data[0]
+        wgt_sc = next(init for init in model.graph.initializer if init.name == "WGT_scale").float_data[0]
+
+        # Return quantization parameters
+        return act_zp, act_sc, wgt_zp, wgt_sc
+
+    def test_default(self):
+        """
+        Test default behavior without specifying the MinimumRealRange option.
+        """
+        act_zp, act_sc, wgt_zp, wgt_sc = self.perform_quantization(
+            self.zero_range_activations,
+            self.zero_range_weights,
+            min_real_range=None,  # default behavior
+        )
+
+        # No minimum real range is set. Expect default behavior (scale = 1.0, zp = 0)
+        self.assertEqual(act_zp, 0)
+        self.assertEqual(act_sc, 1.0)
+        self.assertEqual(wgt_zp, 0)
+        self.assertEqual(wgt_sc, 1.0)
+
+    def test_min_real_range(self):
+        """
+        Test a MinimumRealRange value of 0.0001.
+        """
+        min_real_range = 0.0001
+
+        act_zp, act_sc, wgt_zp, wgt_sc = self.perform_quantization(
+            self.zero_range_activations,
+            self.zero_range_weights,
+            min_real_range=min_real_range,
+        )
+
+        expected_scale = np.float32(min_real_range / 255)
+
+        # Minimum floating-point range is set. Expect small scale values.
+        self.assertEqual(act_zp, 0)
+        self.assertEqual(act_sc, expected_scale)
+        self.assertEqual(wgt_zp, 0)
+        self.assertEqual(wgt_sc, expected_scale)
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/onnxruntime/test/python/quantization/test_quant_util.py b/onnxruntime/test/python/quantization/test_quant_util.py
index 6efa279393..65cdff025b 100644
--- a/onnxruntime/test/python/quantization/test_quant_util.py
+++ b/onnxruntime/test/python/quantization/test_quant_util.py
@@ -33,6 +33,18 @@ class TestQuantUtil(unittest.TestCase):
         self.assertEqual(compute_scale_zp(-tiny_float, tiny_float, 0, 255, symmetric=True), [0, 1.0])
         self.assertEqual(compute_scale_zp(-tiny_float, 0.0, 0, 255, symmetric=False), [0, 1.0])
 
+        # Test enforcing a minimum floatint-point range.
+        self.assertEqual(compute_scale_zp(0.0, 0.0, 0, 255, symmetric=False, min_real_range=0.0001), [0, 0.0001 / 255])
+        self.assertEqual(
+            compute_scale_zp(0.0, 0.0, -128, 127, symmetric=True, min_real_range=0.0001), [0, 0.0002 / 255]
+        )
+        self.assertEqual(
+            compute_scale_zp(0.0, 0.0, 0, 65535, symmetric=False, min_real_range=0.0001), [0, 0.0001 / 65535]
+        )
+        self.assertEqual(
+            compute_scale_zp(0.0, 0.0, -32768, 32767, symmetric=True, min_real_range=0.0001), [0, 0.0002 / 65535]
+        )
+
     def test_load_external_model(self):
         input_name = "input"
         output_name = "output"