diff --git a/.pipelines/nuget_config/x64/packages.config b/.pipelines/nuget_config/x64/packages.config
index 65f6c30a6b..77ee9f45d8 100644
--- a/.pipelines/nuget_config/x64/packages.config
+++ b/.pipelines/nuget_config/x64/packages.config
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <packages>
   <package id="python" version="3.7.9" targetFramework="native" />
-  <package id="Microsoft.AI.DirectML" version="1.10.0" targetFramework="native" />
+  <package id="Microsoft.AI.DirectML" version="1.10.1" targetFramework="native" />
   <package id="Microsoft.Windows.CppWinRT" version="2.0.201201.7" targetFramework="native" />
 </packages>
diff --git a/.pipelines/nuget_config/x86/packages.config b/.pipelines/nuget_config/x86/packages.config
index 9ca4eb1623..d1b41eec64 100644
--- a/.pipelines/nuget_config/x86/packages.config
+++ b/.pipelines/nuget_config/x86/packages.config
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <packages>
   <package id="pythonx86" version="3.7.9" targetFramework="native" />
-  <package id="Microsoft.AI.DirectML" version="1.10.0" targetFramework="native" />
+  <package id="Microsoft.AI.DirectML" version="1.10.1" targetFramework="native" />
   <package id="Microsoft.Windows.CppWinRT" version="2.0.201201.7" targetFramework="native" />
 </packages>
diff --git a/cmake/external/dml.cmake b/cmake/external/dml.cmake
index 61d6484edf..78813fa449 100644
--- a/cmake/external/dml.cmake
+++ b/cmake/external/dml.cmake
@@ -40,7 +40,7 @@ if (NOT onnxruntime_USE_CUSTOM_DIRECTML)
   set(NUGET_CONFIG ${PROJECT_SOURCE_DIR}/../NuGet.config)
   set(PACKAGES_CONFIG ${PROJECT_SOURCE_DIR}/../packages.config)
   get_filename_component(PACKAGES_DIR ${CMAKE_CURRENT_BINARY_DIR}/../packages ABSOLUTE)
-  set(DML_PACKAGE_DIR ${PACKAGES_DIR}/Microsoft.AI.DirectML.1.10.0)
+  set(DML_PACKAGE_DIR ${PACKAGES_DIR}/Microsoft.AI.DirectML.1.10.1)
   set(DML_SHARED_LIB DirectML.dll)
 
   # Restore nuget packages, which will pull down the DirectML redist package.
diff --git a/packages.config b/packages.config
index ece227a3d8..4e0348458b 100644
--- a/packages.config
+++ b/packages.config
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <packages>
   <package id="GoogleTestAdapter" version="0.17.1" targetFramework="net46" />
-  <package id="Microsoft.AI.DirectML" version="1.10.0" targetFramework="native" />
+  <package id="Microsoft.AI.DirectML" version="1.10.1" targetFramework="native" />
   <package id="Microsoft.Windows.CppWinRT" version="2.0.201201.7" targetFramework="native" />
 </packages>
diff --git a/tools/nuget/generate_nuspec_for_native_nuget.py b/tools/nuget/generate_nuspec_for_native_nuget.py
index ca82de2451..db2e4d2e1d 100644
--- a/tools/nuget/generate_nuspec_for_native_nuget.py
+++ b/tools/nuget/generate_nuspec_for_native_nuget.py
@@ -181,7 +181,7 @@ def generate_repo_url(line_list, repo_url, commit_id):
 
 
 def generate_dependencies(xml_text, package_name, version):
-    dml_dependency = '<dependency id="Microsoft.AI.DirectML" version="1.10.0"/>'
+    dml_dependency = '<dependency id="Microsoft.AI.DirectML" version="1.10.1"/>'
 
     if package_name == "Microsoft.AI.MachineLearning":
         xml_text.append("<dependencies>")