diff --git a/onnxruntime/core/providers/webnn/builders/helper.h b/onnxruntime/core/providers/webnn/builders/helper.h
index af4780323f..93d36e7761 100644
--- a/onnxruntime/core/providers/webnn/builders/helper.h
+++ b/onnxruntime/core/providers/webnn/builders/helper.h
@@ -167,6 +167,7 @@ static const InlinedHashMap<std::string, std::string> op_map = {
     {"Not", "logicalNot"},
     {"Pad", "pad"},
     {"Pow", "pow"},
+    {"PRelu", "prelu"},
     {"Reciprocal", "reciprocal"},
     {"ReduceMax", "reduceMax"},
     {"ReduceMean", "reduceMean"},
diff --git a/onnxruntime/core/providers/webnn/builders/impl/binary_op_builder.cc b/onnxruntime/core/providers/webnn/builders/impl/binary_op_builder.cc
index ac08f7a3f2..8ae9ad6b2f 100644
--- a/onnxruntime/core/providers/webnn/builders/impl/binary_op_builder.cc
+++ b/onnxruntime/core/providers/webnn/builders/impl/binary_op_builder.cc
@@ -39,6 +39,8 @@ Status BinaryOpBuilder::AddToModelBuilderImpl(ModelBuilder& model_builder, const
     output = model_builder.GetBuilder().call<emscripten::val>("div", input0, input1);
   } else if (op_type == "Pow") {
     output = model_builder.GetBuilder().call<emscripten::val>("pow", input0, input1);
+  } else if (op_type == "PRelu") {
+    output = model_builder.GetBuilder().call<emscripten::val>("prelu", input0, input1);
   } else {
     return ORT_MAKE_STATUS(ONNXRUNTIME, INVALID_ARGUMENT,
                            "BinaryOpBuilder::AddToModelBuilderImpl, unknown op: ", op_type);
@@ -59,6 +61,7 @@ void CreateBinaryOpBuilder(const std::string& op_type, OpBuilderRegistrations& o
           "Mul",
           "Div",
           "Pow",
+          "PRelu",
       };
 
   op_registrations.builders.push_back(std::make_unique<BinaryOpBuilder>());
diff --git a/onnxruntime/core/providers/webnn/builders/op_builder_factory.cc b/onnxruntime/core/providers/webnn/builders/op_builder_factory.cc
index 80f89d8f44..2536ae0ae4 100644
--- a/onnxruntime/core/providers/webnn/builders/op_builder_factory.cc
+++ b/onnxruntime/core/providers/webnn/builders/op_builder_factory.cc
@@ -37,6 +37,7 @@ static OpBuilderRegistrations CreateOpBuilderRegistrations() {
     CreateBinaryOpBuilder("Mul", op_registrations);
     CreateBinaryOpBuilder("Div", op_registrations);
     CreateBinaryOpBuilder("Pow", op_registrations);
+    CreateBinaryOpBuilder("PRelu", op_registrations);
   }
 
   {  // Ternary