diff --git a/onnxruntime/python/tools/quantization/calibrate.py b/onnxruntime/python/tools/quantization/calibrate.py
index dc95cbabbb..1c633ec8e1 100644
--- a/onnxruntime/python/tools/quantization/calibrate.py
+++ b/onnxruntime/python/tools/quantization/calibrate.py
@@ -242,7 +242,9 @@ def main():
     args = parser.parse_args()
     calibrate_op_types = args.op_types.split(',')
     black_nodes = args.black_nodes.split(',')
+    black_nodes = [x for x in black_nodes if x]
     white_nodes = args.white_nodes.split(',')
+    white_nodes = [x for x in white_nodes if x]
     model_path = args.model_path
     output_model_path = args.output_model_path
     images_folder = args.dataset_path