diff --git a/onnxruntime/python/tools/quantization/qdq_loss_debug.py b/onnxruntime/python/tools/quantization/qdq_loss_debug.py
index 4983811c21..a3adf675d8 100644
--- a/onnxruntime/python/tools/quantization/qdq_loss_debug.py
+++ b/onnxruntime/python/tools/quantization/qdq_loss_debug.py
@@ -167,7 +167,7 @@ def _add_pre_post_qdq_pair(
     pre_qdq_tensors: Optional[Sequence[numpy.ndarray]],
     post_qdq_tensors: Optional[Sequence[numpy.ndarray]],
 ) -> None:
-    if post_qdq_tensors and pre_qdq_tensors:
+    if post_qdq_tensors is not None and pre_qdq_tensors is not None:
         qdq_cmp[activation_name] = {}
         qdq_cmp[activation_name]["pre_qdq"] = pre_qdq_tensors
         qdq_cmp[activation_name]["post_qdq"] = post_qdq_tensors
@@ -229,7 +229,7 @@ def create_activation_matching(
 
     for act_name, act_values in qdq_cmp.items():
         float_acts = float_activations.get(act_name)
-        if float_acts:
+        if float_acts is not None:
             act_values["float"] = float_acts
 
     return qdq_cmp
diff --git a/onnxruntime/test/python/quantization/test_qdq_loss_debug.py b/onnxruntime/test/python/quantization/test_qdq_loss_debug.py
index b09d8d7748..5a26cd3611 100644
--- a/onnxruntime/test/python/quantization/test_qdq_loss_debug.py
+++ b/onnxruntime/test/python/quantization/test_qdq_loss_debug.py
@@ -20,6 +20,7 @@ import onnxruntime
 from onnxruntime.quantization import QuantFormat, QuantType, quantize_static
 from onnxruntime.quantization.calibrate import CalibrationDataReader
 from onnxruntime.quantization.qdq_loss_debug import (
+    QUANT_INPUT_SUFFIX,
     collect_activations,
     compute_activation_error,
     compute_weight_error,
@@ -318,6 +319,12 @@ class TestSaveActivations(unittest.TestCase):
             dq_array = matched_weights[weight_name]["dequantized"]
             self.assertEqual(float_array.shape, dq_array.shape)
 
+    def test_none_test(self):
+        a = np.array([2, 3, 4])
+        b = np.array([7, 8, 9])
+        c = np.array([1, 2, 3])
+        create_activation_matching({"test" + QUANT_INPUT_SUFFIX: a, "test": c}, {"test": b})
+
 
 if __name__ == "__main__":
     unittest.main()