diff --git a/cmake/onnxruntime_python.cmake b/cmake/onnxruntime_python.cmake
index 8f2f55c69c..2411717001 100644
--- a/cmake/onnxruntime_python.cmake
+++ b/cmake/onnxruntime_python.cmake
@@ -75,13 +75,13 @@ add_dependencies(onnxruntime_pybind11_state ${onnxruntime_pybind11_state_depende
 if (MSVC)
   # if MSVC, pybind11 looks for release version of python lib (pybind11/detail/common.h undefs _DEBUG)
   target_link_libraries(onnxruntime_pybind11_state ${onnxruntime_pybind11_state_libs} ${onnxruntime_EXTERNAL_LIBRARIES} ${PYTHON_LIBRARY_RELEASE} ${ONNXRUNTIME_SO_LINK_FLAG})
+elseif (APPLE)
+  set_target_properties(onnxruntime_pybind11_state PROPERTIES LINK_FLAGS "-undefined dynamic_lookup")
+  target_link_libraries(onnxruntime_pybind11_state ${onnxruntime_pybind11_state_libs} ${onnxruntime_EXTERNAL_LIBRARIES} ${ONNXRUNTIME_SO_LINK_FLAG})
+  set_target_properties(onnxruntime_pybind11_state PROPERTIES INSTALL_RPATH "@loader_path")
 else()
   target_link_libraries(onnxruntime_pybind11_state ${onnxruntime_pybind11_state_libs} ${onnxruntime_EXTERNAL_LIBRARIES} ${PYTHON_LIBRARY} ${ONNXRUNTIME_SO_LINK_FLAG})
-  if (APPLE)
-    set_target_properties(onnxruntime_pybind11_state PROPERTIES INSTALL_RPATH "@loader_path")
-  else()
-    set_target_properties(onnxruntime_pybind11_state PROPERTIES LINK_FLAGS "-Xlinker -rpath=\$ORIGIN")
-  endif()
+  set_target_properties(onnxruntime_pybind11_state PROPERTIES LINK_FLAGS "-Xlinker -rpath=\$ORIGIN")
 endif()
 
 set_target_properties(onnxruntime_pybind11_state PROPERTIES PREFIX "")
diff --git a/setup.py b/setup.py
index ea32fa84bf..2a8954809d 100644
--- a/setup.py
+++ b/setup.py
@@ -23,7 +23,7 @@ except ImportError:
     bdist_wheel = None
 
 # Additional binaries
-if platform.system() == 'Linux':
+if platform.system() == 'Linux' or platform.system() == 'Darwin':
   libs = ['onnxruntime_pybind11_state.so', 'libmkldnn.so.0', 'libmklml_intel.so', 'libiomp5.so']
 else:
   libs = ['onnxruntime_pybind11_state.pyd', 'mkldnn.dll', 'mklml.dll', 'libiomp5md.dll']