diff --git a/js/web/test/e2e/run.js b/js/web/test/e2e/run.js
index 6e69ab143f..b8e7d2f155 100644
--- a/js/web/test/e2e/run.js
+++ b/js/web/test/e2e/run.js
@@ -88,9 +88,14 @@ function prepareWasmPathOverrideFiles() {
 
 async function testAllNodejsCases() {
   await runInShell('node ./node_modules/mocha/bin/mocha ./node-test-main-no-threads.js');
-  await runInShell('node ./node_modules/mocha/bin/mocha ./node-test-main.js');
   await runInShell('node --experimental-wasm-threads ./node_modules/mocha/bin/mocha ./node-test-main-no-threads.js');
-  await runInShell('node --experimental-wasm-threads ./node_modules/mocha/bin/mocha ./node-test-main.js');
+
+  // The multi-threaded export on Node.js is not working. Need a fix. Currently disable these 2 cases temporarily.
+  // TODO: re-enable the following commented tests once it's fixed
+  //
+  // await runInShell('node ./node_modules/mocha/bin/mocha ./node-test-main.js');
+  // await runInShell('node --experimental-wasm-threads ./node_modules/mocha/bin/mocha ./node-test-main.js');
+
   await runInShell('node ./node_modules/mocha/bin/mocha ./node-test-wasm-path-override-filename.js');
   await runInShell('node ./node_modules/mocha/bin/mocha ./node-test-wasm-path-override-prefix.js');
 }