Currently, the official ONNXRuntime Python wheel (v1.3.0 onwards) hosted on PyPi requires [Visual C++ 2019 runtime ](https://support.microsoft.com/en-us/help/2977003/the-latest-supported-visual-c-downloads) installed on the target machine.
If the Python wheel is built from source using the build toolset provided with Visual Studio 2017, it will work with the Visual C++ 2017 runtime.
CPython 3.7 is distributed with a VC++ 2017 runtime. Unlike the earlier VC++ version, VC++ 2017 Runtime is binary backward compatible with VC++ 2015. Which means you could build your application with VC++ 2015 then run it with VC++ 2017 runtime.